Studies on specific groups

The beneficial effects of Actimel have been researched for more than 15 years. During this time, 24 publications of clinical studies have been conducted on over 3000 subjects supporting the health benefits of Actimel. They show that Actimel helps support the body's defences*.


Actimel and children


Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt and gelled milk: influence on intestinal microflora in healthy infants

Guerin-Danan C, Chabanet C, Pedone C, Popot F, Vaissade P, Bouley C, Szylit O, Andrieux C.

Am J Clin Nutr. 1998 Jan;67(1):111-7.
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The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres

Pedone CA, Bernabeu AO, Postaire ER, Bouley CF, Reinert P.

Int J Clin Pract. 1999 Apr-May;53(3):179-84.
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Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea

Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P.

Int J Clin Pract. 2000 Nov;54(9):568-71.
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Feasibility studies to control acute diarrhoea in children by feeding fermented milk preparations Actimel and Indian Dahi

Agarwal KN, Bhasin SK.

Eur J Clin Nutr. 2002 Dec;56 Suppl 4:S56-9.
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Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study

Sýkora J, Valecková K, Amlerová J, Siala K, Dedek P, Watkins S, Varvarovská J, Stozický F, Pazdiora P, Schwarz J.

J Clin Gastroenterol. 2005 Sep;39(8):692-8.
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A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis

Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G.

Pediatr Res. 2007 Aug;62(2):215-20.
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Effect of Lactobacillus casei DN-114001 application on the activity of fecal enzymes in children after liver transplantation

Pawlowska J, Klewicka E, Czubkowski P, Motyl I, Jankowska I, Libudzisz Z, Teisseyre M, Gliwicz D, Cukrowska B.

Transplant Proc. 2007 Dec;39(10):3219-21.
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A new randomized double blind controlled study measuring Actimel effects on natural defences of 599 children during winter period. (awaiting publication)

Presented in Congresses

Actimel and Seniors


Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study

Turchet P, Laurenzano M, Auboiron S, Antoine JM.

J Nutr Health Aging. 2003;7(2):75-7.
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Daily ingestion of fermented milk containing Lactobacillus casei DN114-001 improves innate-defence capacity in healthy middle-aged people

Parra MD, Martínez de Morentin BE, Cobo JM, Mateos A, Martínez JA.

J Physiol Biochem. 2004 Jun;60(2):85-91.
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Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei

Parra D, De Morentin BM, Cobo JM, Mateos A, Martinez JA.

J Nutr Health Aging. 2004;8(4):208-11.
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Actimel, stress and natural defences


The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001 on the immune response of subjects under academic examination stress

Marcos A, Wärnberg J, Nova E, Gómez S, Alvarez A, Alvarez R, Mateos JA, Cobo JM.

Eur J Nutr. 2004 Dec;43(6):381-9.
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The effect of fermented milk containing Lactobacillus casei on the immune response to exercise

Pujol P, Huguet J, Drobnic F, Banquells M, Ruiz O, Galilea P, Segarra N, Aguilera S, Burnat A, Mateos JA, Postaire ER.

Sports Med, Training and Rehab. 2000;9(3):209-223.
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Actimel and the usage of antibiotics


Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial

Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ.

BMJ. 2007 Jul 14;335(7610):80.
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*Actimel helps support your body's natural defences when 1-2 bottles are consumed everyday as part of a balanced diet and a healthy lifestyle.

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The beneficial effects of Actimel have been researched for more than 15 years

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*When 1-2 bottles are consumed everyday as part of a balanced diet and a healthy lifestyle

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