Published clinical studies demonstrating global beneficial effects of Actimel daily
consumption on natural defences:
A randomized prospective double blind controlled trial on effects of long-term consumption
of fermented milk containing Lactobacillus casei in pre-school children with allergic
asthma and/or rhinitis
Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G.
Pediatr Res. 2007 Aug;62(2):215-20.
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Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial
Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ.
BMJ. 2007 Jul 14;335(7610):80.
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Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced
Diarrhea: Results from Multicenter, Randomized, Placebo-Controlled Nutritional Trial
Giralt J, Regadera JP, Verges R, Romero J, de la Fuente I, Biete A, Villoria J,
Cobo JM, Guarner F.
Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1213-9.
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Effects of a specially designed fermented milk product containing probiotic Lactobacillus
casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized
double-blind study
Sýkora J, Valecková K, Amlerová J, Siala K, Dedek P, Watkins S, Varvarovská J, Stozický
F, Pazdiora P, Schwarz J.
J Clin Gastroenterol. 2005 Sep;39(8):692-8.
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Published clinical studies supporting Actimel's effects on immune system:
Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei
DN114001 in lactating mothers and their children
Ortiz-Andrellucchi A, Sánchez-Villegas A, Rodríguez-Gallego C, Lemes A, Molero T,
Soria A, Peña-Quintana L, Santana M, Ramírez O, García J, Cabrera F, Cobo J, Serra-Majem
L.
Br J Nutr. 2008 Oct;100(4):834-45.
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The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001
on the immune response of subjects under academic examination stress
Marcos A, Wärnberg J, Nova E, Gómez S, Alvarez A, Alvarez R, Mateos JA, Cobo JM.
Eur J Nutr. 2004 Dec;43(6):381-9.
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The effect of fermented milk containing Lactobacillus casei on the immune response
to exercise
Pujol P, Huguet J, Drobnic F, Banquells M, Ruiz O, Galilea P, Segarra N, Aguilera
S, Burnat A, Mateos JA, Postaire ER.
Sports Med, Training and Rehab. 2000;9(3):209-223.
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New insights in the validation of systemic biomarkers for the evaluation of the
immunoregulatory properties of milk fermented with yogurt culture and Lactobacillus
casei (Actimel®): A prospective trial
Yoon H, Dubarry M, Bouley C, Meredith C, Portier A, Tome D, Renevot O, Blachon JL,
Dugas B, Drewitt P, Postaire E.
Int J Immunotherapy. 1999;15(2):79-89.
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Published clinical studies supporting Actimel's effects on intestinal microflora:
Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt
and gelled milk: influence on intestinal microflora in healthy infants
Guerin-Danan C, Chabanet C, Pedone C, Popot F, Vaissade P, Bouley C, Szylit O, Andrieux
C.
Am J Clin Nutr. 1998 Jan;67(1):111-7.
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Published clinical studies on the survival of the L. casei Imunitass
(DN-114 001 / CNCM I-1518) in the digestive tract:
Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers
after consumption of a fermented milk containing Lactobacillus casei DN-114 001Rif
Rochet V, Rigottier-Gois L, Levenez F, Cadiou J, Marteau P, Bresson JL, Goupil-Feillerat
N, Doré J.
Can J Microbiol. 2008 Aug;54(8):660-7.
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Effects of orally administered Lactobacillus casei DN-114 001 on the composition
or activities of the dominant faecal microbiota in healthy humans
Rochet V, Rigottier-Gois L, Sutren M, Krementscki MN, Andrieux C, Furet JP, Tailliez
P, Levenez F, Mogenet A, Bresson JL, Méance S, Cayuela C, Leplingard A, Doré J.
Br J Nutr. 2006 Feb;95(2):421-9.
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New clinical studies measuring Actimel's benefit on body's natural defences, presented
in international congresses and to be published in 2009